Paul Van Liedekerke

I am currently assistent professor at Ghent University, Belgium.

Interested in numerical models and new conceptual ideas, applications from industry to medicine. I have developed particle-based models such as the Discrete Element Method and Smoothed Particle Hydrodynamics for granular matter dynamics (powders and grains), as well as (bio-) fluids and cellular tissues.

I contribute to the development of Agent-based models, which are methods to predict collective behavior from individual dynamics controlled by rules or differential equations. Applications: cell tumor growth, tissue regeneration, tissue development, biotech .

I teach the courses "Introduction to Mathematical modeling" (Master of pharmaceutical engineering) and "Selected topics in mathematical optimization" (Bio-engineering) .

Image impressions:

Video impressions:

• Simulation growing tumorspheroid with high resolution model. The right side shows the whole spheroid, the left side a cut with cell nuclei visible. Each cell is represented in high detail and various physical variables and subcellular components can be monitored

• Simulation growing spheroid on micro-carrier with high resolution model, see Research

• Simulation Regeneration of hepatocytes in a liver lobule blood vessel network simulated with high resolution model

• Impact of high velocity fluid beam with ceramic material, damage prediction (SPH + peridynamics)

• Free surface flow (dripping) of a visco-elastic fluid (modeled with SPH)

• Red blood cell in plasma flow passing through narrow vessel (SPH)

Key publications:

1. Van Liedekerke P., P., Neitsch, J., Johann, T. et al. A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues. Biomech Model Mechanobiol 19, 189–220 (2020). https://doi.org/10.1007/s10237-019-01204-7

2. Van Liedekerke P., J. Neitsch, T. Johann, K. Alessandri, P. Nassoy and D. Drasdo (2017) Quantitative modeling identifies robust predictable stress response of growing CT-26 tumor spheroids under variable conditions. Plos comp. 24. DOI: Biol 10.1371/journal.pcbi.1006273.

3. Van Liedekerke P., M. Palm, N. Jagiella and D. Drasdo (2015) Simulating tissue mechanics with Agent Based Models: concepts and perspectives. J. Comp. Part. mech2(4) (Invited review).

4. T. Odenthal, B. Smeets, Van Liedekerke P., E. Tijskens, H. Ramon, H. Van Oosterwijck (2013) Contact mechanics of adhesive triangulated bodies and application to a deformable cell model. Plos Comp. Biol 9(10).

5. Van Liedekerke P., Ghysels P., Tijskens E., Samaey G., Roose D. and Ramon H. (2010) Particle based model to simulate the micro-mechanics of a spherical biological cell. Phys. Rev. E 81(1). Selected for the Virtual Journal of Biological Physics Research.

Paul Van Liedekerke,

(PhD, HDR)

Key publications: