% of the reference population has a femoral DC lower than the assessed subject.

cf-PWV (standard):
% of the reference population has a cf-PWV lower than the assessed subject.

General information

Despite the clinical added value of arterial stiffness, clinical application of related parameters, such as cf-PWV, and carotid and femoral Distensibility Coefficient (DC), is still suboptimal, mainly due to two obstacles:

  1. Lack of standardization, making impossible to pool data or to use a fixed cut-off value.
  2. Lack of a Reference Values database.

Therefore, the aim of this application is to be used as a standardization tool for arterial stiffness parameters.

The applied equations for calculating the expected mean and standard deviation of each parameter were extracted from published articles* analyzing data from different European Medical Centres and correspond to a sub-population of Healthy subjects.

This application calculates the parametrs as described in those publications, and it corrects them in case different methodologies are used, to have a standardized outcome.

In the case of the carotid and femoral DC, the percentile indicates what percentage of the reference population has a lower DC (and therefore higher stiffness) while the percentile of the cf-PWV indicates the percentage of the population that has lower PWV (and thefore lower stiffness).

For more detailed information about the databases, parameters and derived equations, you can consulte the following articles*:

* The Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’. European Heart Journal (2010) 31, 2338–2350.

* Reference values for local arterial stiffness. Part A: Carotid artery . Engelen L, Bossuyt J, Ferreira I, Van Bortel L, Reesink KD, Segers P, Stehouwer CD, Laurent S, Boutouyrie P. Paper submitted.

* Reference values for local arterial stiffness. Part B: Femoral artery . Bossuyt J ,Engelen L, Ferreira I, Stehouwer CD , Boutouyrie P, Laurent S, Segers P, Reesink KD, Van Bortel L. Paper submitted.