SELECTED ARTICLES
Heterocyclic chemistry
Cyclopropanes
Cyclobutanones
Heteroallylic halides
Non-proteinogenic amino acids
Synthesis of natural products
Flavour and food chemistry
Biotransformation of terpenes
Molecular Modeling
Fungal Metabolites
Isolation of bioactive natural products from medicinal plants

  

Heterocyclic chemistry
 
·         E. Leemans, S. Mangelinckx, N. De Kimpe, “Novel Synthesis of Chiral Unactivated 2-Aryl-1-benylaziridines”, Synlett, 1265-1268 (2009)
·         F. Colpaert, S. Mangelinckx, G. Verniest, N. De Kimpe, “Asymmetric Synthesis of α-Alkylated N-Sulfinyl Imidates as New Chiral Building Blocks”, J. Org. Chem., 74, 3792-3797 (2009)
·         K. Abbaspour Tehrani, N. De Kimpe, “Syntheses and Transformations of 2-Methyleneaziridines and 2-Methyleneazetidines”, Curr. Org. Chem., 13, 854-877 (2009)
·         R. Surmont, G. Verniest, N. De Kimpe, “Gold-Catalyzed Synthesis of 2-Aryl-3-fluoropyrroles”, Org. Lett., 11, 2920-2923 (2009)
·         M. D’hooghe, S. Dekeukeleire, K. Mollet, C. Lategan, P. Smith, K. Chibale, N. De Kimpe, “Synthesis of Novel 2-Alkoxy-3-amino-3-arylpropan-1-ols and 5-Alkoxy-4-aryl-1,3-oxazinanes with Antimalarial Activity”, J. Med. Chem., 52, 4058-4062 (2009)
·         S. Dekeukeleire, M. D’hooghe, N. De Kimpe, “Diastereoselective Synthesis of Bicyclic γ-Lactams via Ring Expansion of Monocyclic β-Lactams”, J. Org. Chem., 74, 1644-1649 (2009)
·         R. Surmont, G. Verniest, F. Colpaert, G. Macdonald, J. W. Thuring, F. Deroose, N. De Kimpe, “New Synthesis of  3-Fluoropyrroles”, J. Org. Chem., 74, 1377-1380 (2009)
·         E. Van Hende, G. Verniest, F. Deroose, J. W. Thuring, G. Macdonald, N. De Kimpe, “Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic Acid”, J. Org. Chem., 74, 2250-2253 (2009)
·         W. Van Brabandt, S. Mangelinckx, M. D’hooghe, B. Van Driessche, N. De Kimpe, “Synthesis and Reactivity of 3-Haloazetidines and 3-Sulfonyloxyazetidines”, Curr. Org. Chem., 13, 829-853 (2009)
·         R. Surmont, G. Verniest, A. De Weweire, J.-W. Thuring, G. Macdonald, F. Deroose, N. De Kimpe, “Efficient Synthesis of 3-Alkoxy-4,4-difluoropiperidines”, Synlett., 1933-1936 (2009)
·         K. Vervisch, M. D’hooghe, K. Törnroos, N. De Kimpe, “A New Approach Towards 1-Phenyl and 1-Benzyl Substituted 2-(Aminomethyl)cyclopropanecarboxamides as Novel Derivatives of the Antidepressant Milnacipram”, Org. Biomol. Chem.,7, 3271-3279 (2009)
·         E. Van Hende, G. Verniest, J.-W. Thuring, G. Macdonald, F. Deroose N. De Kimpe, “Synthesis of 3-Aminomethyl-3-fluoropiperidines”, Synlett, 1765-1768 (2009)
·         S. Claessens, J. Jacobs, S. Van Aeken, K. Abbaspour Tehrani, N. De Kimpe, “Synthesis of Benzo[f]-isoindole-4,9-diones”, J. Org. Chem., 73, 7555-7559 (2008)
·         M. D’hooghe, C. Buyck, J. Contreras, N. De Kimpe, “Electrophile-induced Bromocyclization of γ,δ-Unsaturated Ketimines to Intermediate 1-Pyrrolinium Salts and Their Selective Conversion into Novel 5-Alkoxymethyl-2-aryl-3-chloropyrroles and 2-Aroylpyrroles”, Org. Biomol. Chem., 6, 3667-3669 (2008)
·         S. Claessens, J. Jacobs, S. Van Aeken, K. Abbaspour Tehrani, N. De Kimpe, “Synthesis of Benzo[f]isoindole-4,9-diones”, J. Org. Chem., 73, 7555-7559 (2008)
·         M. D’hooghe, C. Buyck, J. Contreras, N. De Kimpe, “Electrophile-induced Bromocyclization of γ,δ-Unsaturated Ketimines to Intermediate 1-Pyrrolinium Salts and Their Selective Conversion into Novel 5-Alkoxymethyl-2-aryl-3-chloropyrroles and 2-Aroylpyrroles”, Org. Biomol. Chem., 6, 3667-3669 (2008)
·         G. Verniest, R. Surmont, E. Van Hende, A. Deweweire, F. Deroose, J. W. Thuring, N. De Kimpe, “New Entries Towards 3,3-Difluoropiperidines”, J. Org. Chem., 73, 5458-5461 (2008)
·         J. Jacobs, B. Kesteleyn, N. De Kimpe, “First Straightforward Synthesis of 2,4-Disubstituted Benz[g]isoquinoline-3,5,10(2H)-triones, 1,2,3,5-Substituted Naphtho[3,2,1-de]-isoquinoline-4,7-diones, and 6-Substituted Benz[h]pyrido[3,4,5-kl]-1,2,3,4-tetrahydroacridine-5,8-diones”, Tetrahedron, 64, 7545-7554 (2008)
·         M. D’hooghe, W. Van Brabant, S. Dekeukeleire, Y. Dejaeghere, N. De Kimpe, “Highly Stereoselective Synthesis of β-Lactams Utilizing α-Chloroimines as New and Powerful Chiral Inductors”, Chem. Eur. J., 14, 6336-6340 (2008)
·         M. Karikomi, M. D’hooghe, G. Verniest, N. De Kimpe, “Regio- and Stereocontrolled Synthesis of Novel 3-Sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(Sulfonyloxymethyl)aziridines”, Org. Biomol. Chem., 6, 1902-1904 (2008)
·         J. Jacobs, J. Deblander, B. Kesteleyn, K. Abbaspour Tehrani, N. De Kimpe, “Synthesis of N-Substituted 1,2,3,4-Tetrahydrobenz[g]isoquinoline-5,10-diones”, Tetrahedron, 64, 5345-5353 (2008)
·         S. Mangelinckx, M. Boeykens, N. De Kimpe, “2-(Dichloromethyliden)azetidines: Stable Strained Cyclic Enamines”, Synlett, 1394-1398 (2008)
·         E. Leemans, M. D'hooghe, Y. Dejaegher, K. Törnroos, N. De Kimpe, “Novel Diastereoselective Synthesis of Bicyclic b-Lactams through Radical Cyclization and Their Reduction toward 2-(1-Alkoxy-2-hydroxyethyl)piperidines and 2-(1-Alkoxy-2-hydroxyethyl)azepanes”, J. Org. Chem., 73, 1422-1428 (2008)
·         E. Van Hende, G. Verniest, R. Surmont, N. De Kimpe, “Synthesis of 3-Substiututed 2-Fluoro- and 2,2-difluoroaziridines”, Org. Lett., 9, 2935-2937 (2007)

·         S. Claessens, J. Jacobs, N. De Kimpe, “Synthesis of 2-Aza-1-cyano-4-hydroxyanthraquinones”, Synlett, 741-744 (2007)

·         M. D’hooghe, N. De Kimpe, “Highly Unusual Conversion of 1-Alkyl-2-(bromomethyl)aziridines into 1-alkyl-2-(N-alkylethylaminomethyl)aziridines using methyllithium”, Chem. Commun.,1275-1277 (2007)

·         B. Denolf, E. Leemans, N. De Kimpe, “Asymmetric Synthesis of Aziridines by Reduction of N-tert-Butanesulfinyl α-Chloro Imines”, J. Org. Chem., 72, 3211-3217 (2007)

·         G. S. Singh, M. D’hooghe, N. De Kimpe, “Synthesis and Reactivity of C-Heteroatom-substituted Aziridines”, Chem. Rev.,107, 2080-2135 (2007)

·         M. D’hooghe, M. Boelens, J. Piqueur, N. De Kimpe, “Stereospecific Aziridination of Olefins via Electrophile-induced Cyclisation of γ,δ-Unsaturated Imines and Subsequent Hydrolytic Rearrangement”, Chem. Commun., 1927-1929 (2007)

·         J. Jacobs, S. Claessens, B. Kesteleyn, K. Huygen, N. De Kimpe, “New Synthesis of N-Substituted Benz[g]isoquinoline-3,5,10(2H)-triones”, Tetrahedron, 63, 2503-2510 (2007)

·         W. Van Brabandt, G. Verniest, D. De Smaele, G. Duvey, N. De Kimpe, “Synthesis of 3-fluoroazetidines”, J. Org. Chem., 71, 7100-7102 (2006)

·         B. Denolf, S. Mangelinckx, K. Törnroos, N. De Kimpe, “Use of a-Chlorinated N-(tert-Butanesulfinyl)imines in the Synthesis of Chiral Aziridines”, Org. Lett., 8, 3129-3132 (2006)

·         M. D’hooghe, T. Van Langendonck, K. Törnroos, N. De Kimpe, “Novel Synthesis of cis-3,5-Disubstituted Morpholine Derivatives”, J. Org. Chem., 71, 4678-4681 (2006)

·         W. Van Brabandt, R. Van Landeghem, N. De Kimpe, “Ring Transformation of 2-(Haloalkyl)azetidines into 3,4-Disubstituted Pyrrolidines and Piperidines”, Org. Lett., 8, 1105-1108 (2006)

·         W. Van Brabandt, Y. Dejaegher, R. Van Landeghem, N. De Kimpe, “Reduction of 4-(Haloalkyl)azetidin-2-ones with LiAlH4 as a Powerful Method for the Synthesis of Stereodefined Aziridines and Azetidines”, Org. Lett., 8, 1101-1104 (2006) 

·         W. Van Brabandt, N. De Kimpe, “Electrophile-induced Ring Expansion of β-Lactams toward γ-Lactams”,  J. Org. Chem, 70, 8717-8722 (2005)

·         W. Van Brabandt, N. De Kimpe, “Diastereoselective Ring Expansion of β-Lactams toward γ-Lactams via N-Acyliminium Intermediates”,  J. Org. Chem, 70, 3369-3374 (2005)

·         M. D’hooghe, A. Waterinckx, N. De Kimpe, “A Novel Entry Toward 2-Imino-1,3-thiazolidines and 2-Imino-1,3-thiazolines by Ring Transformation of 2-(Thiocyanomethyl)aziridines”, J. Org. Chem, 70, 227-232 (2005).

·         Y. Dejaegher, N. De Kimpe, “Rearrangement of 4-(1-Haloalkyl)- and 4-(2-Haloalkyl)-2-azetidinones into Methyl ω-Alkylaminopentanoates via Transient Aziridines and Azetidines”, J. Org. Chem., 69, 5974-5974 (2004).

·         S. Mangelinckx, N. Giubellina, N. De Kimpe, “1-Azaallylic Anions in Heterocyclic Chemistry”, Chem. Rev., 104, 2353-2399 (2004).

·         M. D’hooghe, W. Van Brabandt, N. De Kimpe, “New Synthesis of Propargylic Amines from 2-(Bromomethyl)aziridines. Intermediacy of 3-Bromoazetidinium Salts”, J. Org. Chem., 69, 2703-2710 (2004).

·         Y. Dejaegher, S. Mangelinckx, N. De Kimpe, “Rearrangements of 2-Aryl-3,3-dichloroazetidines: Intermediacy of 2-Azetines”, J. Org. Chem., 67, 2075-2081 (2002).
·         Y. Dejaegher, N. Kuzmenok, A. Zvonok, N. De Kimpe, “The Chemistry of Azetidin-3-ones, Oxetan-3-ones, and Thietan-3-ones”, Chem. Rev., 102, 29-60 (2002).
·         K. Abbaspour Tehrani, N. De Kimpe, “New Synthesis of 2-Methyleneaziridines and 2-Methyleneazetidines by Dimethyl Titanocene Mediated Mehylation of a- and b-Lactams”, Tetrahedron Letters, 41, 1975-1978 (2000).
·         W. Aelterman, N. De Kimpe, V. Tyvorskii, O. Kulinkovich, “Synthesis of 2,3-Disubstituted Pyrroles and Pyridines from 3-Halo-1-azaallylic Anions”, J. Org. Chem., 66, 53-58 (2001).
·         T. Nguyen Van, N. De Kimpe, “Synthesis of Chiral Cis-1,2,3-Trisubstituted Aziridines”, Tetrahedron, 56, 7299-7304 (2000).
·         M. Karikomi, N. De Kimpe, “A Novel Synthesis of 3-Aminoazetidines by Ring Transformation of 2-(Bromomethyl)aziridines”, Tetrahedron Letters, 41, 10295-10298 (2000).
·         D. De Smaele, P. Bogaert, N. De Kimpe, “Synthesis of Pyrrolizidines by Cascade Reactions of N-Alkenylaziridinylmethyl Radicals”, Tetrahedron Letters, 39, 9797-9800 (1998).
·         N. De Kimpe, W. Aelterman, K. De Geyter, J.-P. Declercq, "Stereospecific Synthesis of cis-2-Alkoxy-3-aminooxolanes", J. Org. Chem., 62, 5138-5143 (1997).
·         N. De Kimpe, in "Comprehensive Heterocyclic Chemistry II, Three and Four-Membered Rings, with All Fused Systems Containing Four-Membered Rings; Vol. 1B, Chapter 1.18 "Azetidines, Azetines, and Azetes : Monocyclic", p. 507-589; Eds. A. Padwa, A.R. Katritzky, C.W. Rees, E.F.V. Scriven, Pergamon, Elsevier, Oxford, ISBN 0-08-042072-9 (1996).
·         N. De Kimpe, K. Abbaspour Tehrani, G. Fonck, "Synthesis of 4,4-Disubstituted b‑Lactams by Regiospecific Electrophile- and Silver-Induced Ring Expansion of 2,2-Disubstituted 1-Methoxycyclopropylamines", J. Org. Chem., 61, 6500-6503 (1996).

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Cyclopropanes 

 

·         S. Mangelinckx, M. D’hooghe, S. Peeters, N. De Kimpe, “Synthesis of 2-[(Arylmethylene)amino]cyclopropanenitriles via a Two-step Transformation of 2-(Cyanomethyl)aziridines”, Synthesis, 1105-1112 (2009)
·         M. D’hooghe, K. Vervisch, N. De Kimpe, “Synthesis of 1-Arylmethyl-2-(2-cyanoethyl)aziridines and Their Rearrangement into Novel 2-(Aminomethyl)-cyclopropanecarbonitriles”, J. Org. Chem., 72, 7329-7332 (2007)

·         B. Denolf, S. Mangelinckx, K. Törnroos, N. De Kimpe, “Asymmetric Synthesis of Cyclopropylamines Starting from N-Sulfinyl α-Chloro Ketimines”, Org. Lett., 9, 187-190 (2007)

·         M. D’hooghe, S. Mangelinckx, E. Persyn, W. Van Brabandt, N. De Kimpe, “Synthesis of 1-Arylmethyl-2-(cyanomethyl)aziridines and Their Ring Transformation into Methyl N-(2-cyanocyclopropyl)benzimidates”, J. Org. Chem., 71, 4232-4236 (2006)

·         S. Mangelinckx, N. De Kimpe, “Michael-Induced Ring Closure to 2-Azidocyclopropane-1,1-dicarboxylates and their Staudiger Reduction to 5-Alkoxy-3-(alkoxycarbonyl)pyrrolidin-2-ones”, Synlett, 369-374 (2006)

·         G. Verniest, S. Claessens, F. Bombeke,  T. Van Thienen, N. De Kimpe, “Synthesis of 2-Aryl-4-chloropyrroles via Ring Expansion of 2-Aryl-1-chlorocyclopropanecarbaldehydes”, Tetrahedron, 61, 2879-2887 (2005)

·         N. Giubellina, N. De Kimpe, “Functionalized 2-Chlorocyclopropanecarboxylates through the MIRC Reaction”, Synlett, 976-980 (2005).

·         S. Mangelinckx, N. De Kimpe, “Synthesis of Racemic Cis-1-alkyl- and 1-aryl-2-aminocyclopropanecarboxylic Esters”, Tetrahedron Letters, 44, 1771-1774 (2003).

·         Z. Szakonyi, F. Fülöp, D. Tourwé, N. De Kimpe, “Synthesis of 1,2,7,7a-Tetrahydro-1aH-cyclopropa-[b]quinoline-1a-carboxylic Acid Derivatives, Doubly Constrained ACC Derivatives, by a Remarkable Cyclopropanation Process”, J. Org. Chem., 67, 2192-2196 (2002).

·         G. Verniest, F. Bombeke, O. G. Kulinkovich, N. De Kimpe, “Stereoselective Synthesis of cis-2-Aryl- and 2-Alkyl-1-chlorocyclopropanecarboxaldehydes”, Tetrahedron Letters, 43, 599-602 (2002).
·         N. De Kimpe, Methods of Organic Chemistry (Houben-Weyl), Vol. E17B "Carbocyclic Three-Membered Ring Compounds", Chapters 5.2.3.4. to 5.2.3.7., pp. 1603-1694, Ed. A. de Meijere, G. Thieme Verlag, Stuttgart (1997).
·         B. Zwanenburg, N. De Kimpe, Methods of Organic Chemistry (Houben-Weyl), Vol. E.17A (Carbocyclic Three-Membered Ring Compounds", Chapters 1.1.1 and 1.1.3, pp. 29-40 and pp. 45-105, Ed. A. de Meijere, G. Thieme Verlag, Stuttgart (1997).
·         N. De Kimpe, P. Sulmon, L. Moëns, N. Schamp, J.-P. Declercq, M. Van Meerssche, "The Favorskii Rearrangement of a-Chloro-Ketimines", J. Org. Chem., 51, 3839-3848 (1986).

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Cyclobutanones 

·         G. Verniest, S. Claessens, N. De Kimpe, “Stereoselective Reduction of N-(3-Arylcyclobutylidene)-amines”, Tetrahedron Letters, 47, 3299-3302 (2006)

·         G. Verniest, J. Colpaert, K. Törnroos, N. De Kimpe, “New Synthesis of Semisqaric Acid Derivatives via Chlorinated N-(Cyclobutylidene)amines”, J. Org. Chem., 70, 4549-4552 (2005)

·         G. Verniest, N. De Kimpe, “Synthesis of 2(5H)-Furanones via Oxidative Ring Expansion of 4-Hydroxy-2-cyclobutenones”, Synlett., 947-950 (2005)

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Heteroallylic halides 
 
·         N. De Kimpe, R. Verhé, "a-Halogenated Imines", Chapter 13 in "The Chemistry of Functional Groups, Supplement D: The Chemistry of Halides, Pseudo-Halides and Azides", Eds. S. Patai en Z. Rappoport, J. Wiley, p. 549-601 (1983).

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Non-proteinogenic amino acids
 

·         S. Mangelinckx, A. Zukauskaite, V. Buinauskaite, A. Sackus, N. De Kimpe, “Synthesis of Alkyl 2-(bromomethyl)aziridine-2-carboxylates and Alkyl 3-Bromoazetidine-3-carboxylates as Amino Acid Building Blocks”, Tetrahedron Letters, 49, 6896-6900 (2008)

·         L. Kiss, E. Forro, T. Martinek, G. Bernath, N. De Kimpe, F. Fülöp, “Stereoselective Synthesis of Hydroxylated β-Aminocyclohexanecarboxylic Acids”, Tetrahedron, 64, 5036-5043 (2008)

·         L. Kiss, S. Mangelinckx, R. Sillanpää, F. Fülöp, N. De Kimpe, “An Easy Stereoselective Access to β,γ-Aziridino α-Amino Ester Derivatives via Mannich Reaction of Benzophenone Imines of Glycine Esters with N-Sulphonyl α-Chloroaldimines”, J. Org. Chem., 72, 7199-7206 (2007)

·         L. Kiss, S. Mangelinckx, F. Fülöp, N. De Kimpe, “Convenient Synthesis of Trans-β-Amino Carboxylic Esters with an Azetidine Skeleton via Rearrangement of β,γ-Aziridino α-Amino Esters”, Org. Lett., 9, 4399-4402 (2007)

·         Z. Szakonyi, S. Gyonfalvi, E. Forro, A. Hetenyi, N. De Kimpe, F. Fülöp, “Synthesis of 3- and 4-Hydroxy-2-aminocyclohexanecarboxylic Acids by Iodocyclization”, Eur. J. Org. Chem., 4017-4023 (2005)

·         S. Mangelinckx, N. De Kimpe, “Synthesis of N-Protected β-Aminocyclopropanedicarboxylates and Their Ring Transformation to N-Benzhydryl-3-alkoxycarbonyl-4,4-dialkylpyrrolidin-2-ones”, Synlett, 1521-1526 (2005)

·         C. Stevens, G. Smagghe, T. Rammeloo, N. De Kimpe, “Insectrepellent / Antifeedant Activity of 2,4-Methanoproline and Derivatives against a Leaf- and Seed-Feeding Pest Insect”, J. Agric. Food Chem., 53, 1945-1948 (2005)

·         S. Mangelinckx, M. Boeykens, M. Vliegen, J. Van der Eycken, N. De Kimpe, “Synthesis of New 3,3-Dimethoxyazetidine-2-carboxylic Acid Derivatives”, Tetrahedron Letters, 46, 525-529 (2005).
·         Z. Szakonyi, F. Fülöp, D. Tourwé, N. De Kimpe, “Synthesis of 1,2,7,7a-Tetrahydro-1aH-cyclopropa[b]quinoline-1a-carboxylic Acid Derivatives, Doubly Constrained ACC Derivatives, by a Remarkable Cyclopropanation Process”, J. Org. Chem., 67, 2192-2196 (2002).
·          A. Salgado, T. Huybrechts, A. Eeckhaut, J. Van der Eycken, Z. Szakonyi, F. Fülöp, A. Tkachev, N. De Kimpe, “Synthesis of (1S)-1-Amino-2,2-dimethylcyclopropane-1- carboxylic Acid via PLE Mediated Hydrolysis of Bis(2,2,2-trifluoroethyl)-2,2-dimethylcyclopropane-1,1-dicarboxylate”, Tetrahedron, 57, 2781-2786 (2001).
·         J. Czombos, W. Aelterman, A. Tkachev, J. Martins, D. Tourwé, A. Peter, G. Toth, F. Fülöp, N. De Kimpe, “Convenient Synthesis of 3,4-Methano-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid and Its Derivatives as Double Constrained Nonproteinogenic Amino Acid Derivatives”, J. Org. Chem., 65, 5469-5475 (2000).
·         M. Boeykens, N. De Kimpe, K. Abbaspour Tehrani, "Synthesis of 1-Amino-2,2-dialkylcyclopropanecarboxylic Acids via Base-Induced Cyclization of g-Chloro-a-imino Esters", J. Org. Chem., 59, 6973-6985 (1994).

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Synthesis of natural products 
 

·         J. Jacobs, T. Nguyen Van, P. Markusse, C. Stevens, L. Maat, N. De Kimpe, “New Synthesis of 1-[(3,4-Dimethoxyphenyl)methoxymethyl]-6,7-dimethoxyisoquinoline (Setigerine), a Naturally Occurring Alkaloid, and Some Derivatives of Papaverine”, Tetrahedron, 65, 1188-1192 (2009)

·         J. Deblander, S. Van Aeken, J. Jacobs, N. De Kimpe, K. Abbaspour Tehrani, “A New Synthesis of Benzo[f]isoindole-4,9-diones by Radical Alkylation and Bromomethylation of 1,4-Naphthoquinones”, Eur. J. Org. Chem., 4882-4892 (2009)

·         M. E. Riveiro, D. Maes, R. Vazquez, M. Vermeulen, S. Mangelinckx, J. Jacobs, S. Debenedetti, C. Shayo, N. De Kimpe, C. Davio, “Toward Establishing Structure-Activity Relationships for Oxygenated Coumarins as Differentiation Inducers of Promonocytic Leukemic Cells”, Bioorg. Med. Chem., 17, 6547-6559 (2009)

·         N. V. S. Mudiganti, S. Claessens, N. De Kimpe, “The First Asymmetric Synthesis of All Four Isomers of Cis- and Trans-3,4-dihydroxy-3,4-dihydromollugin”, Tetr. Lett., 49, 6980-6983 (2008)

·         N. V. Sastry Mudiganti, S. Claesens, P. Habonimana, N. De Kimpe, “Efficient Synthesis of Cis- and Trans-3,4-dihydroxy-3,4-dihydromollugin”, J. Org. Chem., 73, 3867-3874 (2008)

·         D. Maes, M. E. Riveiro, C. Shayo, C. Davio, S. Debenedetti, N. De Kimpe, “Total Synthesis of Naturally Occurring 5,6,7- and 5,7,8-Trioxygenated Coumarins”, Tetrahedron, 64, 4438-4443 (2008)

·         J. Jacobs, S. Claessens, N. De Kimpe, “First Straightforward Synthesis of 1-Hydroxy-3,4-dihydro-1H-benz[g]isochromene-5,10-dione and Structure Revision of a Bioactive benz[g]isochromene-5,10-dione from Psychotria camponutans”, Tetrahedron, 64, 412-418 (2008)

·         D. Maes, K. Van Syngel, N. De Kimpe, “Synthesis of Artekeiskeanin A: A New Coumarin Monoterpene Ether from Artemisia keiskeana”, Heterocycles, 74, 927-930 (2007)

·         S. Claessens, G. Verniest, J. Jacobs, E. Van Hende, P. Habonimana, T. N. Van, L. Van Puyvelde, N. De Kimpe, “A Survey of Synthetic Routes towards the Pyranonaphthoquinone Antibiotic Pentalongin and Synthesis of the Corresponding Nitrogen Derivatives”, Synlett, 829-850 (2007)

·         Tuyen Nguen Van, S. Claessens, P. Habonimana, K. Abbaspour Tehrani, L. Van Puyvelde, N. De Kimpe, “Synthesis of Harounoside, a Naturally Occurring Pentalongin Hydroquinone Bisglucoside”, Synlett., 2469-2471 (2006)

·         S. Claessens, B. Kesteleyn, T. Nguyen Van, N. De Kimpe, “Synthesis of Mollugin”, Tetrahedron, 62, 8419-8424 (2006)

·         D. Maes, K. Van Syngel, S. Debenedetti, N. De Kimpe, “Synthesis of Purpurasol, a Highly Oxygenated Coumarin from Pterocaulon purpurascens”, Tetrahedron, 62, 4426-4429 (2006)

·         S. Claessens, D. Naidoo, D. Mulholland, L. Verschaeve, J. van Staden, N. De Kimpe, “Synthesis of Pyranonaphthoquinone Antibiotics Involving the Phthalide Annulation Strategy”, Synlett, 621-623 (2006)

·         D. Maes, S. Vervisch, S. Debenedetti, C. Davio, S. Mangelinckx, N. Giubellina, N. De Kimpe, “Synthesis and Structural Revisison of Naturally Occurring Ayapin Derivatives”, Tetrahedron, 61, 2505-2511 (2005).

·         T. Nguyen Van, G. Verniest, S. Claessens, N. De Kimpe, “Total Synthesis of Four Naturally Occurring 2-Azaanthraquinone Antibiotics, 6-Deoxy-8-methylbostryocoidin, 6-Deoxybostrycoidin, 7-O-demethyl-6-deoxybostrycoidin and Scorpinone”, Tetrahedron, 61, 2295-2300 (2005).

·         T. Nguyen Van, M. D’hooghe, S. Pattyn, N. De Kimpe, “Synthesis of Functionalized 1,4-Dihydro-9,10-anthraquinones and Anthraquinones by Ring Closing Metathesis Using Grubb’s Catalyst”, Synlett, 1913-1916 (2004).

·         T. Nguyen Van, N. De Kimpe, “Synthesis of Pyranonaphthoquinone Antibiotics Involving the Ring Closing Metathesis of a Vinyl Ether”, Tetrahedron Letters, 45, 3443-3446 (2004).

·         T. Nguyen Van, S. Debenedetti, N. De Kimpe, “Synthesis of Coumarins by Ring-Closing Metathesis using Grubbs’ Catalyst”, Tetrahedron Letters, 44, 4199-4201 (2003).

·         T. Nguyen Van, N. De Kimpe, “New Synthesis of the Alkaloid Polonicumtoxin C”, Tetrahedron, 56, 7976-7973 (2000).
·         B. Kesteleyn, N. De Kimpe, “Synthesis of Mimosamycin”, J. Org. Chemistry, 65, 636-639 (2000).
·         B. Kesteleyn, N. De Kimpe, “Synthesis of  Two Naphthoquinone Antibiotics, Dehydroherbarin and 6-Deoxybostrycoidin”, J. Org. Chemistry, 65, 640-644 (2000).
·         K. Abbaspour Tehrani, D. Borremans, N. De Kimpe, “Synthesis of 2-Acyl-3-chloropyrroles: Application to the Synthesis of the Trail Pheromone of the Ant Atta texana”, Tetrahedron, 55, 4133-4152 (1999).
·         M. Keppens, N. De Kimpe, "Enantioselective Total Syntheses of the Nitraria Alkaloids (-)-Nitramine and (+)-Isonitramine", J. Org. Chem., 60, 3916-3918 (1995).
·         N. De Kimpe, W. Aelterman, "An Efficient Synthesis of S-(+)-Manicone, an Alarm Pheromone of Manica Ants", Tetrahedron, 52, 12815-12820 (1996).
·         D. Enders, J. Tiebes, N. De Kimpe, M. Keppens, C. Stevens, G. Smagghe, O. Betz, "Enantioselective Synthesis and Determination of the Configuration of Stenusine, the Spreading Agent of the Beetle Stenus comma", J. Org. Chem., 58, 4881-4884 (1993).

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Flavour and food chemistry
 

·         D. Ramonaityte, M. Kersiene, A. Adams, K. Abbaspour Tehrani, N. De Kimpe, “The Interactions of Metal Ions with Maillard Reaction Products in a Lactose-Glycine Model System”, Food Research Int., 42, 331-336 (2009)

·         A. Adams, V. Kitryte, R. Venskutonis, N. De Kimpe, “Formation and Characterization of Melanoidin-like Polycondensation Products from Amino Acids and Lipd Oxidation Products”, Food Chem., 115, 904-911 (2009)

·         A. Adams, V. Polizzi, M. van Boekel, N. De Kimpe, “Formation of Pyrazines and a Novel Pyrrole in Maillard Model ystems of 1,3-Dihydroxyacetone and 2-Oxopropanal”, J. Agric. Food Chem., 56, 2147-2153 (2008)

·         A. Adams, N. De Kimpe, M. van Boekel, “Modification of Casein by the Lipid Oxidation Product Malondialdehyde”, J. Agric. Food Chem., 56, 1713-1719 (2008)

·         W. Jahouach-Rabai, M. Trabelsi, V. Van Hoed, A. Adams, R. Verhé, N. De Kimpe, M. Frikha, “Influence of Bleaching by Ultrasound on Fatty Acids and Minor Compounds of Olive Oil. Qualitative and Quantitative Analysis of Volatile Compounds (by SPME coupled to GC/MS)”, Ultrasonics Sonochem., 15, 590-597 (2008)

·         M. Keršienė, A. Adams, A. Dubra, N. De Kimpe, D. Leskauskaitė, “Interactions between Flavour Release and Rheological Properties in Model Custard Desserts: Effect of Starch Concentration and Milk Fat”, Food Chem., 108, 1183-1191 (2008)

·         A. Adams, N. De Kimpe, “Formation of Pyrazines and 2-Acetyl-1-pyrroline by Bacillus cereus”, Food Chemistry, 101, 1230-1238 (2007)

·         A. Adams, N. De Kimpe, “Chemistry of 2-Acetyl-1-pyrroline, 6-Acetyl-1,2,3,4-tetrahydropyridine, 2-Acetyl-2-thiazoline, and 5-Acetyl-2,3-dihydro-4H-thiazine: Extraordinary Maillard Flavor Compounds”, Chem. Rev., 106, 2295-2319 (2006)

·         L. Vanhaecke, N. Van Hoof, W. Van Brabandt, B. Soenen, A. Heyerick, N. De Kimpe, D. De Keukeleire, W. Verstraete, T. Van de Wiele, “Metabolism of the Food-Associated Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by Human Intestinal Microbiota”, J. Agric. Food Chem., 54, 3454-3461 (2006)

·         A. Adams, R. Borelli, V. Fogliano, N. De Kimpe, ”Thermal degradation Studies of Food Melanoidins”, J. Agric. Food Chemistry, 53, 4136-4142 (2005)

·         A. Adams, K. Abbaspour Tehrani, M. Kersiene, N. De Kimpe, “Detailed Investigation of the Production of the Bread Flavor Component 6-Acetyl-1,2,3,4-tetrahydropyridine in Proline/1,3-Dihydroxyacetone Model Systems”, J. Agric. Food Chem., 52, 5685-5693 (2004).

·         G. Verniest, S. Boterberg, J. Colpaert, T. Van Thienen, C. Stevens, N. De Kimpe, “Synthesis of 2-Substituted Cyclobutanones as g-Irradiation Marker Products of Lipid-Containing Foods”, Synlett, 1273-1275 (2004).

·         J. Taylor, J. Demyttenaere, K. Abbaspour Tehrani, C. Arribas Olave, L. Regniers, L. Verschaeve, A. Maes, E. Elgorashi, J. van Staden, N. De Kimpe, “ Genotoxicity of Melanoidin Fractions Derived from a Standard Glucose/Glycine Model”, J. Agric. Food Chem., 52, 318-323 (2004).

·         C. Obretenov, J. Demyttenaere, K. Abbaspour Tehrani, A. Adams, M. Kersiene, N. De Kimpe, “Flavor Release in the Presence of Melanoidins Prepared from L-(+)-Ascorbic Acid and Amino acids”, J. Agric. Food Chemistry, 50, 4244-4250 (2002).

·         K. Abbaspour Tehrani, M. Kersiene, A. Adams, R. Venskutonis, N. De Kimpe, “Thermal Degradation Studies of Glucose/Glycine Melanoidines”, J. Agric. Food Chem., 50, 4062-4068 (2002).
·         N. De Kimpe, W. Aelterman, "Synthesis of 2-[(Methylthio)methyl]-2-butenal, a Characteristic Flavor Component of Potato Chips, Krill Seasoning, Roasted Coffee, and Yeast Extracts", J. Agric. Food Chem., 44, 3598-3600 (1996).
·         N. De Kimpe, M. Keppens, "Novel Syntheses of the Major Flavor Components of Bread and Cooked Rice", J. Agric. Food Chem., 44, 1515-1519 (1996).
·         N. De Kimpe, W. Dhooghe, Y. Shi, M. Keppens, M. Boelens, "On the Hodge Mechanism of the Formation of the Bread Flavor Component 6-Acetyl-1,2,3,4-tetrahydropyridine from Proline and Sugars", J. Agric. Food Chem., 42, 1739-1742 (1994).
·         N. De Kimpe, C. Stevens, M. Keppens, "Synthesis of 2-Acetyl-1-pyrroline, the Principal Rice Flavor Component", J. Agric. Food Chem., 41, 1458-1461 (1993).
·         N. De Kimpe, C. Stevens, "A Convenient Synthesis of 6-Acetyl-1,2,3,4-tetrahydropyridine, the Principle Bread Flavor Component", J. Org. Chem., 58, 2904-2906 (1993).

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Biotransformation of terpenes
 

·         J. Demyttenaere, J. Vanoverschelde, N. De Kimpe, “Biotransformation of (R)-(+)- and (S)-(-)-Citronello by Aspergillus sp. and Penicillium sp., and the Use of solid-phase Microextraction for Screening”, J. Chrom. A, 1027, 137-146 (2004).

·         A. Adams, J. Demyttenaere, N. De Kimpe, “Biotransformation of (R)-(+)- and (S)-(-)-Limonene to a-Terpineol by Penicillium digitatum – Investigation of the Culture Conditions”, Food Chem., 80, 525-534 (2003).

·         J. Demyttenaere, A. Adams, K. Van Belleghem, N. De Kimpe, W. A. König, A. Tkachev, “De novo Production of (+)-Aristolochene by Sporulated Squrface Cultures of Penicillium roqueforti”, Phytochem., 59, 597-602 (2002).
·         J. Demyttenaere, A. Adams, J. Van Overschelde, N. De Kimpe, “Biotransformation of (S)-(+)-Linalool by Aspergillus niger: An Investigation of the Culture Conditions”, J. Agric. Food Chem., 49, 5895-5901 (2001).
·         J. Demyttenaere, M. del Carmen Herrera, N. De Kimpe, “Biotransformation of Geraniol, Nerol and Citral by Sporulated Surface Cultures of Aspergillus niger and Penicillium sp.”, Phytochemistry, 55, 363-373 (2000).

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Molecular Modeling 
 

·         R. Declerck, D. De Sterk, T. Verstraelen, G. Verniest, S. Mangelinckx, N. De Kimpe, M. Waroquier, V. Van Speybroeck, “Insight into the Solvation and Isomerization of 3-Halo-1-azaallylic Anions from Ab Initio Metadynamics Calculations and NMR Experiments”, Chem. Eur. J., 15, 580-584 (2009)

·         S. Y. Yun, S. Catak, W. K. Lee, M. D’hooghe, N. De Kimpe, V. Van Speybroeck, M. Waroquier, “Nucleophile-dependent Regioselective Ring Opening of 2-Substituted N,N-Dibenzylaziridinium Ions: Bromide versus Hydride”, Chem. Commun., 2508-2510 (2009)

·         B. De Sterck, V. Van Speybroeck, S. Mangelinckx, G. Verniest, N. De Kimpe, M. Waroquier, “Theoretical Study on the Structural Properties of Various Solvated Metalated 3-Halo-1-azaallylic Anions” J. Phys. Chem. A, 113, 6375-6380 (2009)

·         S. Mangelinckx, V. Van Speyboeck, P. Van Steenkiste, M. Waroquier, N. De Kimpe, “Experimental and Computational Study of the Conrotatory Ring Opening of Various 3-Chloro-2-azetines”, J. Org. Chem., 73, 5481-5488 (2008)

·         M. D’hooghe, V. Van Speybroeck, A. Van Nieuwenhove, M. Waroquier, N. De Kimpe, “Novel Synthesis of 3,4-Diaminobutenenitriles and 4-Amino-2-butenenitriles from 2-(Cyanomethyl)aziridines through Intermediate Aziridinium Salts: An Experimental and Theoretical approach”, J. Org. Chem., 72, 4733-4740 (2007)

·         P. Van Steenkiste, V. Van Speybroeck, G. Verniest, N. De Kimpe, M. Waroquier, “Applicability of the Hindered Rotor Scheme to the Puckering Mode in Four-Membered Rings”, J. Phys. Chem. A, 110, 3838-3844 (2006)

·         M. D’hooghe, V. Van Speybroeck, M. Waroquier, N. De Kimpe, “Regio- and Stereospecific Ring Opening of 1,1-Dialkyl-2-aryloxymethyl)aziridinium Salts by Bromide”, Chem. Commun., 1554-1556 (2006)

·         V. Van Speybroeck, N. De Kimpe, M. Waroquier, “N-Alkenyl-2-aziridinylmethyl radicals and N-alkenylaminyl Radicals in Cascade Cyclizations to Pyrrolizidines and Indolizidines”, J. Org. Chem, 70, 3674-3681 (2005)

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Fungal Metabolites
 

·         F. Van Lancker, A. Adams, B. Delmulle, S. De Saeger, A. Moretti, C. Van Peteghem, N. De Kimpe, “Use of Headspace-SPME-GC-MS for the Analysis of the Volatiles Produced by Indoor Molds Grown on Different Substrates”, J. Environ. Monit., 10, 1127-1133 (2008)

·         B. Delmulle, S. De Saeger, A. Adams, N. De Kimpe, C. Van Peteghem, “Development of a Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of 16 Mycotoxins on Cellulose Filters and in Fungal Cultures”, Rapid Commun. Mass Spectrom., 20, 771-776 (2006) 

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Isolation of bioactive natural products from medicinal plants 
 

·         H. Lii, J. Chen, W. Li, B. Ren, J. Wu, H. Kang, H. Zhang, A. Adams, N. De Kimpe, “Hypoglycemic and Hypolipidemic Effects of the Total Triterpene Acid Fraction from Folium Eriobotryae”, J. Ethnopharm., 122, 486-491 (2009)

·         Q. Zhang, L. Qin, W. He, L. Van Puyvelde, D. Maes, A. Adams, H. Zheng, N. De Kimpe, “Coumarines from Cnidium monnieri and their Antiosteoporotic Activity”, Planta Medica, 73, 13-19 (2007)

·         D. Maes, S. Debenedetti, N. De Kimpe, “New Coumarins from Pterocaulon virgatum (L.) DC”, Biochem. Systematics Ecol., 34, 165-169 (2006)

·         N. Germonprez, L. Maes, L. Van Puyvelde, M. Van Tri, D. Anh Tuan, N. De Kimpe, “In vitro and in vivo Anti-Leishmanial Activity of Triterpenoid Saponins Isolated from Maesa balansae and Some Chemical Derivatives”, J. Med. Chem., 48, 32-37 (2005).

·         M. E. Riveiro, C. Shayo, F. Monczor, N. Fernandez, A. Baldi, N. De Kimpe, J. Rossi, S. Debenedetti, C. Davio, “Induction of Cell Differentiation in Human Leukemia U-937 Cells by 5-Oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum”, Cancer Letters, 210, 179-188 (2004).

·         L. Verschaeve, V. Kerstens, J. Taylor, E. Elgorashi, A. Maes, L. Van Puyvelde, N. De Kimpe, J. van Staden, “Investigation of the Antimutagenic Effects of Selected South African Medicinal Plant Extracts”, Toxicology in Vitro, 18, 29-35 (2004).

·         D. Domondon, W. He, N. De Kimpe, M. Höfte, J. Poppe, “b-Adenosine, a Bioactive Compound in Grass Chaff Stimulating Mushroom Production”, Phytochemistry, 65, 181-187 (2004).

·         L. Maes, D. Vanden Berghe, N. Germonprez, L. Quirijnen, P. Cos, N. De Kimpe, L. Van Puyvelde, “In vitro and in vivo Activities of a Triterpenoid Saponin Extract (PX-6518) from the Plant Maesa balansae against Visceral Leishmania species”, Antimicrobial Agents and Chemotherapy, 48, 130-136 (2004).

·         J. Bukuru, T. Nguyen Van, L. Van Puyvelde, W. He, N. De Kimpe, “New Pentacyclic Cyclol-type Naphthohydroquinone from the Roots of Pentas bussei”, Tetrahedron, 59, 5905-5908 (2003).

·         E. Elgorashi, J. Taylor, A. Maes, J. van Staden, N. De Kimpe, L. Verschaeve, “Screening of Medicinal Plants used in South African Traditional Medicine for Genotoxic Effects”, Toxicol. Letters, 143, 195-207 (2003).

·         W. He, M. Cik, L. Van Puyvelde, J. Van Dun, G. Appendino, A. Lesage, I. Van der Linden, J. Leysen, W. Wouters, S. Mathenge, F. Mudida, N. De Kimpe, “Neurothophic and Antileukemic Daphnane Diterpenoids from Synaptolepis kirkii”, Bioorg. Med. Chem., 10, 3245-3255 (2002).

·         J. Bukuru, T. Nguyen Van, L. Van Puyvelde, S. Mathenge, F. Mudida, N. De Kimpe, “A Benzochromene from the Roots of Pentas bussei”, J. Natural Prod., 65, 783-785 (2002).
·          W. He, L. Van Puyvelde, J. Bosselaers, N. De Kimpe, M. Van der Flaas, A. Roymans, S. Mathenge, F. Mudida, “Antifouling Substances of Natural Origin: Activity of Benzoquinone Compounds from Maesa lanceolata against Marine Crustaceans”, Biofouling, 17, 221-226 (2001).
·          W. He, M. Cik, A. Lesage, I. Van der Linden, N. De Kimpe, G. Appendino, J. Bracke, S. Mathenge, F. Mudida, J. Leysen,  L. Van Puyvelde, “Kirkinine, A New Daphnane Orthoester with Potent Neurotrophic Activity From Synaptolepis kirkii”, J. Nat. Products, 63, 1185-1187 (2000).
·          S. L. Debenedetti, E. L. Nadinic, J. D. Coussio, N. De Kimpe, M. Boeykens, “Two 6,7-Dioxygenated Coumarins from Pterocaulon virgatum”, Phytochemistry, 48, 707-710 (1998).
·         N. De Kimpe, N. Schamp, L. Van Puyvelde, S. Dubé, M. Chagnon-Dubé, F. Borremans, M. J. O. Anteunis, J.-P. Declercq, G. Germain, M. Van Meerssche, "Isolation and Structural Identification of 8(14),15-Sandaracopimaradiene-7a,18-diol from Iboza riparia", J. Org. Chem., 47, 3628-3630 (1982).

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